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KMID : 0370220210650040276
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Yakhak Hoeji
2021 Volume.65 No. 4 p.276 ~ p.283
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Utilization trends of Proton Pump Inhibitors in South Korea: Analysis using 2016-2020 Healthcare Bigdata Hub by Health Insurance Review and Assessment Service
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Oh Joo-Ah
Lee Gyu-Min
Chung Seo-Yeon
Cho Yu-Song
Lee Hye-Jae
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Abstract
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Proton Pump Inhibitors (PPIs) are drugs that inhibit gastric acid secretion and are widely used globally. Withthe aging population and the rising prevalence of gastrointestinal diseases in Korea, the number of patients using PPIs isincreasing. Therefore, we investigated the current state of PPI utilization at the national level using the nationwidedatabase, Healthcare Bigdata Hub compiled by the Health Insurance Review and Assessment Service (HIRA). Weextracted the statistics from 2016 to 2020 and re-organized them into monthly utilization by treatments. The cost andvolume of use by region, provider type, and diagnostic code were extracted for five PPIs: pantoprazole, rabeprazole,omeprazole, esomeprazole, and lansoprazole. The volume of use was converted into Defined Daily Dose (DDD), whichis the standardized unit of utilization. Esomeprazole and rabeprazole were the most commonly used PPIs, andesomeprazole has shown a sharp increase recently. The crude utilization of each region was the highest in Seoul, but thatin Daegu and Jeonbuk was the highest after adjusting for the population size. The utilization of PPIs has increased in alldiagnostic codes, and Gastroesophageal Reflux Disease (GERD) accounts for the highest proportion. Despite emergingconcerns on the adverse outcomes of long-term PPI utilization, their consumption has increased in recent years. Theseresults on the variations by region and trends by diagnostic code thus address a good basis for future research and policiesregarding PPIs.
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KEYWORD
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Proton pump inhibitors, Omeprazole, Esomeprazole, Rabeprazole, Lansoprazole, Pantoprazole, Gastroesophageal reflux disease
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